Gastrointestinal Stromal Tumors (GIST) are rare tumors that develop in the digestive tract, most commonly in the stomach or small intestine. They arise from specialized cells in the GI tract wall called interstitial cells of Cajal, which help coordinate muscle contractions. GISTs can be benign or malignant and may grow slowly or aggressively. Symptoms may be vague, including abdominal pain, bleeding, or a mass. Diagnosis and treatment often involve imaging, biopsy, surgery, and targeted therapy based on mutation analysis.